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This indicates that GSTM1 primes astrocytes for inflammatory responses by enhancing microglia activation through the release of these mediators, thus emphasizing the importance of glialglial communication in regulating neuroinflammatory processes and their implications for depression [123]

Your healthcare team can discuss whether switching to an alternative agent or trying a different class of diabetes medication (such as SGLT2 inhibitors or DPP-4 inhibitors) might be appropriate for your individual circumstances, in line with NICE guidance

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